DNA Replication

Contents

DNA Replication

postulate replication
Francis Crick proposed 3 models for how DNA might replicate. Credit: Jeremy Seto (CC-BY 3.0)

Meselson & Stahl Experiment

Meselson and Stahl
Meselson & Stahl revealed semi-conservative replication as the method through use of radiolabeling DNA in bacteria. Credit: Jeremy Seto (CC0)

Reference:

Meselson M, Stahl FW. THE REPLICATION OF DNA IN ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1958 Jul 15;44(7):671-82. doi: 10.1073/pnas.44.7.671. PMID: 16590258; PMCID: PMC528642.

Replication Machinery

DNA replication split

OSC Microbio 11 02 RepFork
The replication fork. Credit: CNX Openstax (CC-BY 4.0)

 

Reference:

Okazaki R, Okazaki T, Sakabe K, Sugimoto K, Sugino A. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains. Proc Natl Acad Sci U S A. 1968 Feb;59(2):598-605. doi: 10.1073/pnas.59.2.598. PMID: 4967086; PMCID: PMC224714.

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