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Translocation
Translocation is the movement of a piece or a whole chromosome onto another chromosome. The acrocentric nature of Chr 21 and it’s small size makes it prone to an event called Robertsonian Translocation whereby two acrocentric chromosomes fuse.
![Robertsonian translocation rob(14;21)](http://upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Robertsonian_translocation_rob%2814%3B21%29.png/512px-Robertsonian_translocation_rob%2814%3B21%29.png)
![Brain Cancer Chromosomes](https://farm2.staticflickr.com/1442/26003749480_0a00752af2.jpg)
Abnormalities in mitosis also occur and can result in diseases from translocations.
Tags: applied knowledge, life-long learning