Please view the posters presented at the 18th Annual CityTech Faculty and Student Research Poster Session below. You can click on each poster to enlarge it and view the PDF version under the poster abstract.
We thank all presenters for sharing their innovative and informative research with the CityTech community and beyond!
29. Protein Instability in Medicinal Applications of Gadolinium Complexes
Lanthanides like Gadolinium are useful in medicinal and radiological chemistry. They can be used to eliminate free radicals and act as antioxidants in vivo. However, this affinity for reactive oxygen species also create competitive binding of lanthanides to proteins. This alters biologically important electron transfer pathways, for example in bones and in brain and renal tissues. This could cause toxicity. We have been working on the molecular interaction of Gadolinium with egg proteins. In order to understand experimental results molecular modeling is being performed for long range dispersive forces that are attractive at large ionic distances but have attractive nature at short range. It is interesting that some Gadolinium complexes can break down the 3D protein structures faster depending on ligands. Hence it is necessary to revisit the hydrogen bonding and other weak molecular interactions in such systems. View or download a PDF version of this poster.
