Please view the posters presented at the 18th Annual CityTech Faculty and Student Research Poster Session below. You can click on each poster to enlarge it and view the PDF version under the poster abstract.
We thank all presenters for sharing their innovative and informative research with the CityTech community and beyond!
10. A Synthetic Pathway To Medicinal Natural Products
The Angucyclines constitute a large pool of natural products with a broad array of medicinal properties including antitumor and antibacterial properties. The most interesting ones such as Aquayamycin, with potential anti-HIV activity, constitutes a great synthetic challenge due to the presence of oxygen functionalities at the BC ring junction. Success in the installation of the Hydroxyl groups of the ring junction would pave the way for the synthesis of various members of the class. We have developed a concise and efficient approach to the construction of the oxygenated core of the natural products. Our synthetic approach focuses on the coupling a suitably substituted Phthalide and an activated Alkyne through a tandem Michael addition/Dieckmann cyclization. We describe the successful implementation of our synthetic strategy to generate the ABC ring system of the oxygenated natural products. View or download a PDF version of this poster.
