According to the Arestin professional website, Arestin, minocycline 1 mg microspheres, is a concentrated, locally applied antibiotic that remains active in the pocket for an extended period of time to reduce pocket depth. The microspheres release antibiotic over time, targeting bacteria to reduce pocket depth, so gums can heal better than with scaling and root planing (SRP) alone. Arestin is not indicated for bone loss prevention or BOP. Therefore, the best candidate for Arestin treatment would have 5-7mm pocket depths.
In December 2019, I treated a patient with Arestin. He had Type III periodontitis that was stabilized with oral prophylactic treatment. The patient reported “no discomfort whatsoever” during Arestin placement. He was diligent in following aftercare instructions, and was very satisfied with the effectiveness of Arestin.