Microbiology 3302 Lecture

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  • Enterococcus Faecium aka "Super Bug"
  • #22664

    Kelly Smith
    Participant

    Hi, Iā€™m Enterococcus Faecium. Itā€™s for the best if you and I DONā€™T meet in the hospital. Me and the other enterococci in my family Enterococcaceae are the leading cause of nosocomial infections.
    Iā€™m a part of the normal intestinal flora of humans and animals. Iā€™m particularly well suited to the gastrointestinal track, vaginal tract, and oral cavity because Iā€™m a facultative anaerobeā€”I gain energy through fermentation. Plus, those spots provide me with loads of nutrients. But Iā€™m not exactly fastidious. My gram-positive cell wall has a thick layer of peptidogycan, as well as eichoic and lipoteichoic acids. I can grow in a wide range of temperaturesā€”from 10-45 degrees Celsius. I can also tolerate basic and acidic environments as well as isotonic and hypertonic solutions. I can survive in soil, sewage, and hide out on a variety of hospital surfaces. Iā€™m small (1-2 mm), spherical, and I prefer to hang out in pairs or chains. Iā€™m not motile, but, believe me, I get around!
    When I turn pathogenic, you better WATCH OUT! They donā€™t call me a ā€œsuper bugā€ for nothing. My main weapon, my virulence factor, is my ability to resist to loads of different types of antibioticsā€”vancomycin, penicillin, gentamicin, tetracycline, erythromycin and teicoplanin just to name a few. Iā€™m well known for being resistant to vancomycin. Healthcare workers stay on high alert for VREā€”vancomycin-resistant enterococci.
    I can easily share drug resistance with my own generation and with future generations via plasmids and conjugative transposons. I have a surface protein that allows me to form biofilms so itā€™s easy for me to coordinate with my fellow colony cells and make sure weā€™re all drug resistant. Forming biofilms helps me to colonize hospital tubing, which can lead to blood and urinary tract infections. I can also travel on hands and medical instruments to infect surgical wounds.
    However, Iā€™m not all bad. I have a few helpful uses. I can make antibacterial peptides called bacteriocins. Plus I can ferment delicious cheese and vegetables.

    Hereā€™s video all about me: http://mobile.ztopics.com/Enterococcus%20faecium/

    Hereā€™s a flattering photo of me: http://www.bioquell.asia/interface/assets/images/content/Enterococcus_faecium_faecalis_41503729_1.jpg

    Sources:

    http://en.wikipedia.org/wiki/Enterococcus_faecium

    https://microbewiki.kenyon.edu/index.php/Enterococcus_faecium

    http://emedicine.medscape.com/article/216993-overview

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